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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and mutation, with several innovative platforms, which provides various technical means in this persisting combat. Derived from collaborated researches, vaccines based on the spike protein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19. Herein, we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine strategies are also summarized. Likewise, new technologies may provide more potent or broader immunity and will contribute to fight against hypermutated SARS-CoV-2 variants. All in all, with the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease, alongside the traditional routes, the discovery of innovative approach to developing effective vaccines based on virus properties remains our top priority.

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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Special issue: Near-net shaping technology

Dequn LI, Dongming GUO, Qingxue HUANG, Yanchun LOU

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 1-2 doi: 10.1007/s11465-018-0497-7

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Fungal diversity and its mechanism of community shaping in the milieu of sanitary landfill

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1370-6

Abstract:

• Ascomycota was the predominant phylum in sanitary landfill fungal communities.

Keywords： Sanitary landfill     Fungal community     Diversity     Saprotroph     Physical habitat     Environmental factor    

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen     root system architecture     phytohormone     crosstalk     nitrogen-use efficiency     breeding strategy    

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Binary Optics Used in High Power Laser Shaping

Jin Guopan,Tan Qiaofeng,Yan Yingbai,Wu Minxian

Strategic Study of CAE 2000, Volume 2, Issue 6,   Pages 27-32

Abstract:

The principle of binary optics used for beam shaping is introduced.

Keywords： beam shaping     binary optics     phase element     optimization algorithm    

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H∞ control in the frequency domain for a semi-active floor isolation system

Yundong SHI, Tracy C BECKER, Masahiro KURATA, Masayoshi NAKASHIMA

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 3,   Pages 264-275 doi: 10.1007/s11709-013-0214-x

Abstract: Semi-active control with an control was adopted for the floor isolation system and a new input shaping

Keywords： semi-active     floor isolation     H∞ control     MR damper     shaping filter     shaking table    

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The shape control over the front-end of excimer laser beam

Zhao Xueqing,Xue Quanxi,Zheng Guoxin,Huang Ke,Xiao Weiwei,Yi Aiping,Liu Jingru

Strategic Study of CAE 2009, Volume 11, Issue 8,   Pages 52-57

Abstract: scattering source satisfying requirement of system construction has been developed, and the top-hat laser shaping

Keywords： excimer laser     beam smoothing     uniformity     pulse shaping     high power    

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A Versatile Flow-Profile Engineering Method in the Stokes Flow Regime for Complex-Shaped Flows Article

Zhenyu Yang, Lang Nan, Ho Cheung Shum

Engineering 2021, Volume 7, Issue 5,   Pages 655-662 doi: 10.1016/j.eng.2021.02.008

Abstract:

Flow profiles are frequently engineered in microfluidic channels for enhanced mixing, reaction control, and material synthesis. Conventionally, flow profiles are engineered by inducing inertial secondary flow to redistribute the streams, which can hardly be reproduced in microfluidic environments with negligible inertial flow. The employed symmetric channel structures also limit the variety of achievable flow profiles. Moreover, each of the flow profiles specifically corresponds to a strictly defined flow condition and cannot be generalized to other flow environments. To address these issues, we present a systematic method to engineer the flow profile using inertialess secondary flow. The flow is manipulated in the Stokes regime by deploying a cascaded series of microsteps with various morphologies inside a microchannel to shape the flow profile. By tuning the shapes of the microsteps, arbitrary outflow profiles can be customized. A numerical profile-transformation program is developed for rapid prediction of the output profiles of arbitrary sequences of predefined microsteps. The proposed method allows the engineering of stable flow profiles, including asymmetric ones, over a wide range of flow conditions for complex microfluidic environmental prediction and design.

Keywords： Microfluidics     Flow profile     Stokes flow     Hydrodynamic focusing     Flow shaping    

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A subband excitation substitute based scheme for narrowband speech watermarking Article

Wei LIU, Ai-qun HU

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 5,   Pages 627-643 doi: 10.1631/FITEE.1601503

Abstract: We propose a new narrowband speech watermarking scheme by replacing part of the speech with a scaled and spectrally shaped hidden signal. Theoretically, it is proved that if a small amount of host speech is modified, then not only an ideal channel model for hidden communication can be established, but also high imperceptibility and good intelligibility can be achieved. Furthermore, a practical system implementation is proposed. At the embedder, the power normalization criterion is first imposed on a passband watermark signal by forcing its power level to be the same as the original passband excitation of the cover speech, and a synthesis filter is then used to spectrally shape the scaled watermark signal. At the extractor, a bandpass filter is first used to get rid of the out-of-band signal, and an analysis filter is then employed to compensate for the distortion introduced by the synthesis filter. Experimental results show that the data rate is as high as 400 bits/s with better bandwidth efficiency, and good imperceptibility is achieved. Moreover, this method is robust against various attacks existing in real applications.

Keywords： Narrowband speech watermarking     Passband excitation replacement     Power normalization     Spectral envelope shaping    

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Wavelength-selective wavefront shaping by metasurface Correspondence

Zixin CAI, Xin HE, Xin LIU, Shijie TU, Xinjie SUN, Paul BECKETT, Aditya DUBEY, Arnan MITCHELL, Guanghui REN, Xu LIU, Xiang HAO,xinhe.wins@outlook.com,guanghui.ren@rmit.edu.au,haox@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 4,   Pages 617-625 doi: 10.1631/FITEE.2200510

Abstract: 精确的、与波长相关的相位调制在许多领域中是必不可少的，比如超分辨成像、全彩色全息、微纳加工以及光通讯。这一要求很难通过单一的传统光学元件实现，一般需要使用多个光学元件组合完成。本文提出一种可以实现波长选择性波前整形的超表面设计方法。具体来说，本文设计了一种超表面，它能够对785 nm波长的光做涡旋相位调制，同时不影响590 nm波长的光保持原有相位分布。本文通过干涉仪以及对应点扩散函数的测量来验证不同波长下的波前分布。与已提出的空间复用方式以及色散工程的方法相比，我们提出的设计方法更加直接，优化难度小，适用于需要波长选择性编码的光学系统。本文所提平面光学器件对于需要波长选择性编码的光学系统具有重要应用意义。

Keywords： 超表面；波长选择性；涡旋光；波前整形    

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Title Author Date Type Operation

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

Special issue: Near-net shaping technology

Dequn LI, Dongming GUO, Qingxue HUANG, Yanchun LOU

Journal Article

Fungal diversity and its mechanism of community shaping in the milieu of sanitary landfill

Journal Article

ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Journal Article

Binary Optics Used in High Power Laser Shaping

Jin Guopan,Tan Qiaofeng,Yan Yingbai,Wu Minxian

Journal Article

H∞ control in the frequency domain for a semi-active floor isolation system

Yundong SHI, Tracy C BECKER, Masahiro KURATA, Masayoshi NAKASHIMA

Journal Article

The shape control over the front-end of excimer laser beam

Zhao Xueqing,Xue Quanxi,Zheng Guoxin,Huang Ke,Xiao Weiwei,Yi Aiping,Liu Jingru

Journal Article

A Versatile Flow-Profile Engineering Method in the Stokes Flow Regime for Complex-Shaped Flows

Zhenyu Yang, Lang Nan, Ho Cheung Shum

Journal Article

A subband excitation substitute based scheme for narrowband speech watermarking

Wei LIU, Ai-qun HU

Journal Article

Wavelength-selective wavefront shaping by metasurface

Zixin CAI, Xin HE, Xin LIU, Shijie TU, Xinjie SUN, Paul BECKETT, Aditya DUBEY, Arnan MITCHELL, Guanghui REN, Xu LIU, Xiang HAO,xinhe.wins@outlook.com,guanghui.ren@rmit.edu.au,haox@zju.edu.cn

Journal Article